Hydrochloric Acid → N-{3-[2-(4-Aminopyridin-2-yl)ethyl]phenyl}-2-chloro-5-fluoropyrimidin-4-amine Dihydrochloride

Participants

Reaction Steps

To a mixture of tert-butyl [2-(2-{3-[(2-chloro-5-fluoropyrimidin-4-yl)amino]phenyl}ethyl)pyridin-4-yl]carbamate (123 mg, 0.28 mmol) in 1,4-dioxane (0.51 mL) was added 4 M hydrogen chloride in 1,4-dioxane (1.21 mL). The resultant reaction mixture was stirred at rt for 1 hour. The reaction mixture was concentrated under vacuum to provide the desired product as an off-white powder (113 mg, 98%). LCMS for C17H16ClFN5 (M+H)+: m/z=344.0.

Provenance & Evidence