Hydrochloric Acid → N-{3-[(Z)-2-(4-Aminopyridin-2-yl)vinyl]phenyl}-2,5-dichloropyrimidin-4-amine Dihydrochloride

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Reaction Steps

To a mixture of tert-butyl [2-((Z)-2-{3-[(2,5-dichloropyrimidin-4-yl)amino]phenyl}vinyl)pyridin-4-yl]carbamate (73.6 mg, 0.16 mmol) in 1,4-dioxane (0.50 mL) was added 4 M of hydrogen chloride in 1,4-dioxane (0.70 mL). The resultant reaction mixture was stirred at rt for 1 hour. The reaction mixture was concentrated under vacuum to give the desired product as a light yellow powder (66 mg, 95%). LCMS for C17H14Cl2N5 (M+H)+: m/z=358.0.

Provenance & Evidence