Potassium Carbonate → HCID 57961759, compound

Participants

Reaction Steps

To a solution of 1-(bromomethyl)-3-nitro-benzene (4.50 g, 0.021 mol) and tert-butyl (3-aminophenyl)carbamate (4.34 g, 0.021 mol) in N,N-dimethylformamide (50 mL) was added potassium carbonate (4.32 g, 0.03 mol). The resultant mixture was stirred at room temperature overnight and the reaction was complete. The reaction mixture was filtered first to remove K2CO3, and then quenched with water. EtOAc was added and the layers were separated. The aqueous layer was extracted with EtOAc twice. The combined organic layers were washed with water and then dried (Na2SO4), filtered and concentrated to give the desired product as a light brown gel (6.94 g, 97%). LCMS for C18H22N3O4 (M+H)+: m/z=344.1.

Provenance & Evidence