4-Methylbenzoyl Chloride → HCID 57961608, compound

HRID 541880Notes

Reaction equation

HRID 541880 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[NH:6][C:7]3[CH:8]=[CH:9][CH:10]=[C:11]([CH:23]=3)[CH2:12][NH:13][C:14]3[CH:22]=[C:18]([NH:19][C:20]=1[N:21]=2)[CH:17]=[CH:16][CH:15]=3.[CH3:24][C:25]1[CH:33]=[CH:32][C:28]([C:29](Cl)=[O:30])=[CH:27][CH:26]=1>>[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[NH:6][C:7]3[CH:8]=[CH:9][CH:10]=[C:11]([CH:23]=3)[CH2:12][N:13]([C:29](=[O:30])[C:28]3[CH:32]=[CH:33][C:25]([CH3:24])=[CH:26][CH:27]=3)[C:14]3[CH:22]=[C:18]([NH:19][C:20]=1[N:21]=2)[CH:17]=[CH:16][CH:15]=3

Participants

3

Reactant 2

HCID 134054-Methylbenzoyl ChlorideHCID 57961661HCID 57961661, compound

Product 1

HCID 57961608HCID 57961608, compoundYield 48%

Procedure

The desired compound was prepared as a white powder according to the procedure of Example C22, step F, using 6-chloro-2,4,8,14,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaene and 4-methylbenzoic acid chloride as the starting materials in 48% yield. LCMS for C25H21ClN5O (M+H)+: m/z=442.0.

Sources & evidence

ORD record
ord-a9024d51fc2040d0a78c90757c77374c
Source dataset
uspto-grants-2014_10
Patent number
US08871753B2

Reaction notes

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