2-Thiophenecarbonyl chloride → HCID 57961606, compound

HRID 541881Notes

Reaction equation

HRID 541881 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[NH:6][C:7]3[CH:8]=[CH:9][CH:10]=[C:11]([CH:23]=3)[CH2:12][NH:13][C:14]3[CH:22]=[C:18]([NH:19][C:20]=1[N:21]=2)[CH:17]=[CH:16][CH:15]=3.[S:24]1[CH:28]=[CH:27][CH:26]=[C:25]1[C:29](Cl)=[O:30]>>[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[NH:6][C:7]3[CH:8]=[CH:9][CH:10]=[C:11]([CH:23]=3)[CH2:12][N:13]([C:29]([C:25]3[S:24][CH:28]=[CH:27][CH:26]=3)=[O:30])[C:14]3[CH:22]=[C:18]([NH:19][C:20]=1[N:21]=2)[CH:17]=[CH:16][CH:15]=3

Participants

3

Reactant 2

HCID 789282-Thiophenecarbonyl chlorideHCID 57961661HCID 57961661, compound

Product 1

HCID 57961606HCID 57961606, compoundYield 34%

Procedure

The desired compound was prepared as a white powder according to the procedure of Example C22, step F, using 6-chloro-2,4,8,14,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaene and 2-thiophenecarbonyl chloride as the starting materials in 34% yield. LCMS for C22H17ClN5OS (M+H)+: m/z=434.0.

Sources & evidence

ORD record
ord-2d180e8a10014e48bdd3ff19aa28fb7a
Source dataset
uspto-grants-2014_10
Patent number
US08871753B2

Reaction notes

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