Hydrochloric Acid → 2-[2-(5-Aminopyridin-3-yl)ethyl]-N(4)-(2-chloro-5-fluoropyrimidin-4-yl)benzene-1,4-diamine Trihydrochloride

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Reaction Steps

Into the reaction flask was added tert-butyl [5-(2-{2-[(tert-butoxycarbonyl)amino]-5-[(2-chloro-5-fluoropyrimidin-4-yl)amino]phenyl}ethyl)pyridin-3-yl]carbamate (0.050 g, 0.089 mmol), methanol (0.6 mL), and 4.0 M of hydrogen chloride in 1,4-dioxane (1 mL). The mixture was stirred at rt overnight and concentrated under vacuum to give the desired product (10 mg, 95%). LCMS for C17H17ClFN6 (M+H)+: m/z=359.0.

Provenance & Evidence