(3-Aminopyrazin-2-yl)methanol → 3-Aminopyrazine-2-carbaldehyde

HRID 54189Notes

Reaction equation

HRID 54189 reaction equation
[NH2:1][C:2]1[C:3]([CH2:8][OH:9])=[N:4][CH:5]=[CH:6][N:7]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[NH2:1][C:2]1[C:3]([CH:8]=[O:9])=[N:4][CH:5]=[CH:6][N:7]=1

Participants

4

Reactant 1

HCID 33728543(3-Aminopyrazin-2-yl)methanol

Product 1

HCID 152749313-Aminopyrazine-2-carbaldehydeYield 82%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6212ChloroformSolvent

Procedure

A suspension of 3-aminopyrazine methanol, 6.3 g (0.05 mol) and manganese dioxide (38.0 g) in 400 mL of chloroform is stirred at room temperature for two hours and the resulting solid is filtered off. The filtrate is evaporated to dryness which gives the desired product as a yellow crystalline solid, (5.00 g, 82% yield) having a melting point 110°-114° C.

Workup

  1. filtrationthe resulting solid is filtered off
  2. customThe filtrate is evaporated to dryness which

Sources & evidence

ORD record
ord-96ccdfecee1f445c85446637f344e57f
Source dataset
uspto-grants-1997_04
Patent number
US05622913

Reaction notes

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