Ethanol → HCID 54387339, compound

HRID 5419Notes

Reaction equation

HRID 5419 reaction equation
[CH2:1]=[C:2]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][S:7][CH2:6][C@@H:5]([C:15]([OH:17])=[O:16])[NH:4][C:3]1=[O:18].[CH2:19](O)[CH3:20]>>[CH2:1]=[C:2]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][S:7][CH2:6][C@@H:5]([C:15]([O:17][CH2:19][CH3:20])=[O:16])[NH:4][C:3]1=[O:18]

Participants

3

Reactant 2

HCID 702EthanolHCID 53744040HCID 53744040, compound

Product 1

HCID 54387339HCID 54387339, compound

Procedure

(3R)-6-Methylidene-5-oxo-1-thia-4-azacyclotridecane-3-carboxylic acid (0.16 g), 0.62 mmol) is dissolved in ethanol (5 ml) and hydrogen chloride gas is bubbled through the solution for 5 minutes. The solution is stirred overnight at room temperature and the solvent is evaporated to give ethyl (3R)-6-methylidene-5-oxo-1-thia-4-azacyclotridecane-3-carboxylate, m.p. 146°-147° C.

Workup

  1. customhydrogen chloride gas is bubbled through the solution for 5 minutes
  2. customthe solvent is evaporated

Sources & evidence

ORD record
ord-2e9b771a72464fd2a4cf50637c02194b
Source dataset
uspto-grants-1993_09
Patent number
US05244889

Reaction notes

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