Cesium carbonate → HCID 57962622, compound

Participants

Reaction Steps

Into the reaction was added N-{3-[2-(5-aminopyridin-3-yl)ethyl]-4-methoxyphenyl}-2,5-dichloropyrimidin-4-amine (1.75 g, 4.48 mmol), 1,4-dioxane (29 mL), N,N-dimethylformamide (29 mL), palladium acetate (30 mg, 0.1 mmol), (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (90 mg, 0.2 mmol), and cesium carbonate (2.92 g, 8.97 mmol). The mixture was degassed with N2 bubbling and then microwaved at 150° C. for 20 min. After concentration to remove the solvent, 20 mL of water was added to the residue. The formed precipitate was then collected by vacuum filtration and air dried overnight to give the desired product (1.35 g, 85%). LCMS for C18H17ClN5O (M+H)+: m/z=354.1.

Provenance & Evidence