3-Aminophenol → HCID 57961801, compound

HRID 541916Notes

Reaction equation

Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:10]=[C:11]([CH2:15][OH:16])[CH:12]=[CH:13][CH:14]=2)[C:5]([Cl:17])=[CH:4][N:3]=1.[NH2:18][C:19]1[CH:20]=[C:21]([OH:25])[CH:22]=[CH:23][CH:24]=1>>[Cl:17][C:5]1[C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][OH:16])[CH:10]=2)=[N:7][C:2]([NH:18][C:19]2[CH:20]=[C:21]([OH:25])[CH:22]=[CH:23][CH:24]=2)=[N:3][CH:4]=1

Participants

Reactant 2

HCID 115683-Aminophenol

HCID 57961726HCID 57961726, compound

Product 1

HCID 57961801HCID 57961801, compoundYield 85%

Procedure

The desired compound was prepared according to the procedure of Example D5, step B, using {3-[(2,5-dichloropyrimidin-4-yl)amino]phenyl}methanol and 3-aminophenol as the starting materials in 85% yield. LCMS for C17H16ClN4O2 (M+H)+: m/z=343.1.

Sources & evidence

ORD record: ord-84273e94ae5e421a8681d75aaa531ad5
Source dataset: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08871753B2

Reaction notes

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