2-(3-Aminophenyl)ethan-1-ol → HCID 57961744, compound

HRID 541920Notes

Reaction equation

HRID 541920 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([O:15]C3CCCCO3)[CH:10]=2)[C:5]([Cl:22])=[CH:4][N:3]=1.[NH2:23][C:24]1[CH:25]=[C:26]([CH2:30][CH2:31][OH:32])[CH:27]=[CH:28][CH:29]=1>>[Cl:22][C:5]1[C:6]([NH:8][C:9]2[CH:10]=[C:11]([OH:15])[CH:12]=[CH:13][CH:14]=2)=[N:7][C:2]([NH:23][C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([CH2:30][CH2:31][OH:32])[CH:25]=2)=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 149389872-(3-Aminophenyl)ethan-1-olHCID 57962046HCID 57962046, compound

Product 1

HCID 57961744HCID 57961744, compoundYield 65%

Procedure

The desired compound was prepared according to the procedure of Example D5, step B, using 2,5-dichloro-N-[3-(tetrahydro-2H-pyran-2-yloxy)phenyl]pyrimidin-4-amine and 2-(3-aminophenyl)ethanol [Bioorg. Med. Chem. 2005, 13, 6703-6712] as the starting materials in 65% yield. LCMS for C18H18ClN4O2 (M+H)+: m/z=357.1.

Sources & evidence

ORD record
ord-1412ae5ed25b4b79ad189760f8f9f5b5
Source dataset
uspto-grants-2014_10
Patent number
US08871753B2

Reaction notes

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