3-Aminophenol → HCID 57961741, compound

HRID 541924Notes

Reaction equation

Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=2)[O:12][CH2:13][CH2:14][OH:15])[C:5]([Cl:19])=[CH:4][N:3]=1.[NH2:20][C:21]1[CH:22]=[C:23]([OH:27])[CH:24]=[CH:25][CH:26]=1>>[Cl:19][C:5]1[C:6]([NH:8][C:9]2[CH:18]=[CH:17][CH:16]=[C:11]([O:12][CH2:13][CH2:14][OH:15])[CH:10]=2)=[N:7][C:2]([NH:20][C:21]2[CH:22]=[C:23]([OH:27])[CH:24]=[CH:25][CH:26]=2)=[N:3][CH:4]=1

Participants

Reactant 2

HCID 115683-Aminophenol

HCID 57962226HCID 57962226, compound

Product 1

HCID 57961741HCID 57961741, compoundYield 34%

Procedure

The desired compound was prepared according to the procedure of Example D5, step B, using 2-{3-[(2,5-dichloropyrimidin-4-yl)amino]phenoxy}ethanol and 3-aminophenol as the starting materials in 34% yield. LCMS for C18H18ClN4O3 (M+H)+: m/z=373.0.

Sources & evidence

ORD record: ord-3570cf169f8e45bc8a1d2803c76a14b6
Source dataset: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08871753B2

Reaction notes

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