Water → HCID 57962617, compound

Participants

Reaction Conditions

Reaction Steps

A solution of N-(2,5-dichloropyrimidin-4-yl)-N′-(3-nitrobenzyl)benzene-1,3-diamine trifluoroacetate (67 mg, 0.13 mmol) in methanol (0.51 mL), acetic acid (0.20 mL), and water (0.10 mL) was treated with iron (30 mg, 0.53 mmol) and stirred at 25° C. for 1 h. The reaction mixture was treated with additional iron (25 mg, 0.45 mmol) and stirred at 25° C. for 16 h. The reaction mixture was diluted with methanol (2 mL) and celite was added. The resulting suspension was filtered through a pad of celite and rinsed with methanol. The filtrate was concentrated to give the desired product as a crude residue that was used without further purification.

Provenance & Evidence