HCID 57962033, compound → HCID 57962116, compound

HRID 541935Notes

Reaction equation

HRID 541935 reaction equation
[Si]([O:8][C:9]1[CH:10]=[C:11]([NH:15][C:16]2[C:21]([Cl:22])=[CH:20][N:19]=[C:18](Cl)[N:17]=2)[CH:12]=[CH:13][CH:14]=1)(C(C)(C)C)(C)C.[Br:24][C:25]1[CH:26]=[C:27]([NH:34]C(=O)OC(C)(C)C)[CH:28]=[C:29]([CH2:31][CH2:32][OH:33])[CH:30]=1>>[Br:24][C:25]1[CH:26]=[C:27]([NH:34][C:18]2[N:17]=[C:16]([NH:15][C:11]3[CH:10]=[C:9]([OH:8])[CH:14]=[CH:13][CH:12]=3)[C:21]([Cl:22])=[CH:20][N:19]=2)[CH:28]=[C:29]([CH2:31][CH2:32][OH:33])[CH:30]=1

Participants

3

Reactant 2

HCID 57962033HCID 57962033, compoundHCID 57962486HCID 57962486, compound

Product 1

HCID 57962116HCID 57962116, compoundYield 77%

Procedure

The desired compound was prepared according to the procedure of Example D5, step B, using N-(3-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-2,5-dichloropyrimidin-4-amine and tert-butyl [3-bromo-5-(2-hydroxyethyl)phenyl]carbamate as the starting materials in 77% yield. LCMS for C18H17BrClN4O2 (M+H)+: m/z=434.9, 436.9.

Sources & evidence

ORD record
ord-1839a9bfcd4e49079825b00eb03ea9f0
Source dataset
uspto-grants-2014_10
Patent number
US08871753B2

Reaction notes

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