Pyridine → HCID 66897838, compound

Participants

Reaction Steps

A solution of 6-chloro-2,4,8,15,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaene bis(trifluoroacetate) (10 mg, 18 μmol) in acetonitrile (0.28 mL) was treated with pyridine (7.3 μL, 91 μmol) followed by acetic anhydride (2.1 μL, 22 μmol) and stirred for 16 h. The reaction mixture was quenched with a few drops of acetic acid and purified by preparative LCMS to give the desired product (5 mg, 58%) as a solid. LCMS for C19H17ClN5O (M+H)+: m/z=366.0. 1H NMR (400 MHz, DMSO-d6): δ 9.61 (s, 1H), 9.24 (s, 1H), 8.16 (s, 1H), 8.06 (dd, J=2.0, 1.8 Hz, 1H), 7.93 (s, 1H), 7.32-7.21 (m, 4H), 7.13 (dd, J=8.2, 1.4 Hz, 1H), 6.97 (dd, J=7.8, 1.2 Hz, 1H), 4.61 (br s, 2H), 1.73 (s, 3H).

Provenance & Evidence