Acetic Acid → HCID 57961921, compound

Participants

Reaction Conditions

Reaction Steps

A solution of N-(2,5-dichloropyrimidin-4-yl)-N′-[2-(3-nitrophenoxy)ethyl]benzene-1,3-diamine bis(trifluoroacetate) (100 mg, 0.15 mmol) in methanol (0.63 mL) was treated with acetic acid (0.25 mL, 4.4 mmol), water (0.13 mL, 7.0 mmol), and iron (43 mg, 0.77 mmol) and stirred at 20° C. for 16 h. The reaction mixture was diluted with methanol and treated with celite. The suspension was filtered over a pad of celite and washed with methanol. The filtrate was concentrated to give the desired product (63 mg, 94%) as a crude residue that was used without further purification.

Provenance & Evidence