Potassium Carbonate → HCID 57961824, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2-({3-[(2,5-dichloropyrimidin-4-yl)amino]phenyl}thio)ethyl methanesulfonate (0.17 g, 0.43 mmol) in N,N-dimethylformamide (2 mL) was treated with potassium carbonate (0.15 g, 1.1 mmol) followed by tert-butyl (3-aminophenyl)carbamate (0.17 g, 0.81 mmol) and stirred at 20° C. for 16 h. The reaction mixture was purified by preparative LCMS to give the desired product (23 mg, 10% for 2 steps). LCMS for C23H26Cl2N5O2S (M+H)+: m/z=505.9, 508.0.

Provenance & Evidence