Hydrochloric Acid → HCID 66880938, compound

Participants

Reaction Conditions

Reaction Steps

A solution of tert-butyl 4-(2-bromo-4-nitrophenyl)piperazine-1-carboxylate (2.3 g, 5.9 mmol) in dichloromethane (15 mL) was treated with 4 M HCl in 1,4-dioxane (15 mL, 59 mmol) and stirred at 20° C. for 3 h. The reaction mixture was concentrated, diluted with a minimal amount of methanol (˜15 mL), and added dropwise to ether (300 mL) that was cooled 0° C. The solid that precipitated was collected by filtration and dried to give the desired product (1.9 g, 89%) which was used in the next step without further purification.

Provenance & Evidence