HCID 86636302, compound → HCID 86636301, compound

Participants

Reaction Steps

A solution of N-(tert-butyl)-4-[6-chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]piperazine-1-carboxamide bis(trifluoroacetate) (12 mg, 16 μmol) in trifluoroacetic acid (1 mL) was stirred at 20° C. for 4 h. The reaction mixture was purified by preparative LCMS to give the desired product (8 mg, 72%) as a solid. LCMS for C23H25ClN7O (M+H)+: m/z=450.0. 1H NMR (300 MHz, CD3OD): δ 8.09 (s, 1H), 7.74-7.69 (m, 2H), 7.22-7.11 (m, 2H), 7.04-7.00 (m, 2H), 6.87 (d, J=7.9 Hz, 1H), 3.60 (br s, 4H), 3.14 (s, 4H), 2.89-2.87 (m, 4H).

Provenance & Evidence