Benzoyl chloride → HCID 86636309, compound

Participants

Reaction Steps

A solution of 6-chloro-12-piperazin-1-yl-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaene bis(trifluoroacetate) (30 mg, 47 μmol) and N,N-diisopropylethylamine (41 μL, 0.24 mmol) in dichloromethane was treated with benzoyl chloride (11 μL, 95 μmol) and stirred for 16 h. The reaction mixture was purified by preparative LCMS to give the desired product (14 mg, 40%) as a solid. LCMS for C29H27ClN6O (M+H)+: m/z=511.1. 1H NMR (400 MHz, DMSO-d6): δ 9.54 (br s, 1H), 9.38 (br s, 1H), 8.14 (s, 1H), 7.94 (s, 1H), 7.77 (d, J=2.3 Hz, 1H), 7.47-7.43 (m, 4H), 7.12-7.02 (m, 3H), 6.87-6.82 (m, 2H), 3.79 (br s, 2H), 3.49 (br s, 2H), 2.97 (s, 4H), 2.87-2.79 (m, 4H).

Provenance & Evidence