HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Cyanophenyl isocyanate → (3S)-3-(2-{[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]amino}-2-oxoethyl)-N-(4-cyanophenyl)pyrrolidine-1-carboxamide bis(trifluoroacetate)
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Cyanophenyl isocyanate | HCID 170380 | — |
| Edukt | N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-[(3S)-pyrrolidin-3-yl]acetamide tris(trifluoroacetate) | HCID 86636313 | — |
| Produkt | (3S)-3-(2-{[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]amino}-2-oxoethyl)-N-(4-cyanophenyl)pyrrolidine-1-carboxamide bis(trifluoroacetate) | HCID 86636314 | 60% |
Reaktionsschritte
The desired compound was prepared according to the procedure of Example D41 using N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-[(3S)-pyrrolidin-3-yl]acetamide tris(trifluoroacetate) and 4-isocyanatobenzonitrile as the starting materials in 60% yield. LCMS for C31H29ClN9O2 (M+H)+: m/z=594.0.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08871753B2 |
| Quelldatensatz | uspto-grants-2014_10 |
| ORD ID | ord-b0acc3a6310940a59a10d989b3bb1c44 |
| Quellennotiz | uspto-grants-2014_10 |