5-Methylisoxazole-3-carbonyl chloride → N-[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-{1-[(5-methylisoxazol-3-yl)carbonyl]azetidin-3-yl}acetamide bis(trifluoroacetate)

Participants

Reaction Steps

The desired compound was prepared according to the procedure of Example D94 using 2-azetidin-3-yl-N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]acetamide tris(trifluoroacetate) and 5-methylisoxazole-3-carbonyl chloride as the starting materials in 87% yield. LCMS for C27H26ClN8O3 (M+H)+: m/z=545.0.

Provenance & Evidence