HCID 57962290, compound → HCID 57962657, compound

HRID 541999Notes

Reaction equation

HRID 541999 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([NH:15][CH:16]3[CH2:21][CH2:20][N:19]([C:22]([O:24][CH2:25][C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)=[O:23])[CH2:18][CH2:17]3)=[C:11](I)[CH:10]=2)[C:5]([Cl:33])=[CH:4][N:3]=1.[CH:34]([C:36]1[CH:37]=[C:38]([NH2:42])[CH:39]=[N:40][CH:41]=1)=[CH2:35]>>[NH2:42][C:38]1[CH:37]=[C:36](/[CH:34]=[CH:35]/[C:11]2[CH:10]=[C:9]([NH:8][C:6]3[C:5]([Cl:33])=[CH:4][N:3]=[C:2]([Cl:1])[N:7]=3)[CH:14]=[CH:13][C:12]=2[NH:15][CH:16]2[CH2:21][CH2:20][N:19]([C:22]([O:24][CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)=[O:23])[CH2:18][CH2:17]2)[CH:41]=[N:40][CH:39]=1

Participants

3

Reactant 2

HCID 57962290HCID 57962290, compoundHCID 668802371192475-33-4

Product 1

HCID 57962657HCID 57962657, compoundYield 75%

Procedure

The desired compound was prepared according to the procedure of Example B334, step G, using benzyl 4-({4-[(2,5-dichloropyrimidin-4-yl)amino]-2-iodophenyl}amino)piperidine-1-carboxylate and 5-vinylpyridin-3-amine as the starting materials in 75% yield. LCMS for C30H30Cl2N7O2 (M+H)+: m/z=590.2, 592.1.

Sources & evidence

ORD record
ord-fd3ef34aca8c430daf23ac08f6f28076
Source dataset
uspto-grants-2014_10
Patent number
US08871753B2

Reaction notes

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