HCID 57961898, compound → HCID 57961733, compound

HRID 542006Notes

Reaction equation

HRID 542006 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:30]=[CH:29][C:12]([O:13][CH2:14][CH2:15][CH:16]3[CH2:21][CH2:20][N:19]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:18][CH2:17]3)=[C:11](I)[CH:10]=2)[C:5]([Cl:32])=[CH:4][N:3]=1.[CH:33]([C:35]1[CH:36]=[C:37]([NH2:41])[CH:38]=[N:39][CH:40]=1)=[CH2:34]>>[NH2:41][C:37]1[CH:36]=[C:35](/[CH:33]=[CH:34]/[C:11]2[CH:10]=[C:9]([NH:8][C:6]3[C:5]([Cl:32])=[CH:4][N:3]=[C:2]([Cl:1])[N:7]=3)[CH:30]=[CH:29][C:12]=2[O:13][CH2:14][CH2:15][CH:16]2[CH2:21][CH2:20][N:19]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:18][CH2:17]2)[CH:40]=[N:39][CH:38]=1

Participants

3

Reactant 2

HCID 57961898HCID 57961898, compoundHCID 668802371192475-33-4

Product 1

HCID 57961733HCID 57961733, compoundYield 99%

Procedure

The desired compound was prepared according to the procedure of Example B334, step G, using tert-butyl 4-(2-{4-[(2,5-dichloropyrimidin-4-yl)amino]-2-iodophenoxy}ethyl)piperidine-1-carboxylate and 5-vinylpyridine-3-amine as the starting materials in 99% yield. LCMS for C29H35Cl2N6O3 (M+H)+: m/z=585.3, 587.2.

Sources & evidence

ORD record
ord-859ac7c849374047bf0b55169672e518
Source dataset
uspto-grants-2014_10
Patent number
US08871753B2

Reaction notes

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