Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(Isocyanatomethyl)furan → 4-(2-{[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]oxy}ethyl)-N-(2-furylmethyl)piperidine-1-carboxamide bis(trifluoroacetate)
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(Isocyanatomethyl)furan | HCID 4223811 | — |
| 반응물 | 6-Chloro-12-(2-piperidin-4-ylethoxy)-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaene tris(trifluoroacetate) | HCID 86636347 | — |
| 생성물 | 4-(2-{[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]oxy}ethyl)-N-(2-furylmethyl)piperidine-1-carboxamide bis(trifluoroacetate) | HCID 86636350 | 40% |
반응 단계
The desired compound was prepared according to the procedure of Example D41 using 6-chloro-12-(2-piperidin-4-ylethoxy)-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaene tris(trifluoroacetate) and 2-(isocyanatomethyl)furan as the starting materials in 40% yield. LCMS for C30H33ClN7O3 (M+H)+: m/z=574.1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08871753B2 |
| 출처 데이터셋 | uspto-grants-2014_10 |
| ORD ID | ord-62cfb5ffc55942c08b49a5cbc97491c7 |
| 출처 메모 | uspto-grants-2014_10 |