HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Isocyanatothiophene → 4-(2-{[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]oxy}ethyl)-N-3-thienylpiperidine-1-carboxamide bis(trifluoroacetate)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Isocyanatothiophene | HCID 2776380 | — |
| Reactant | 6-Chloro-12-(2-piperidin-4-ylethoxy)-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaene tris(trifluoroacetate) | HCID 86636347 | — |
| Product | 4-(2-{[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]oxy}ethyl)-N-3-thienylpiperidine-1-carboxamide bis(trifluoroacetate) | HCID 86636351 | 30% |
Reaction Steps
The desired compound was prepared according to the procedure of Example D41 using 6-chloro-12-(2-piperidin-4-ylethoxy)-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaene tris(trifluoroacetate) and 3-isocyanatothiophene as the starting materials in 30% yield. LCMS for C29H31ClN7O2S (M+H)+: m/z=576.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08871753B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-fa5908a42087477ea30ae467e96dad6d |
| Source note | uspto-grants-2014_10 |