1,4-Dioxane → HCID 69014357, compound

Participants

Reaction Steps

A solution of tert-butyl {[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]oxy}acetate (0.76 g, 1.7 mmol) in 4 M HCl in 1,4 dioxane (30 mL, 120 mmol) was heated at 70° C. for 1 h. The reaction mixture was concentrated to a solid that was suspended in diethyl ether, filtered, and washed with diethyl ether to give the desired product (0.82 g, 104%) as a white solid. LCMS for C19H17ClN5O3 (M+H)+: m/z=398.0.

Provenance & Evidence