tert-Butyl piperazine-1-carboxylate → HCID 57962633, compound

HRID 542063Notes

Reaction equation

HRID 542063 reaction equation
Cl.Cl.[Cl:3][C:4]1[CH:5]=[N:6][C:7]2[NH:8][C:9]3[CH:10]=[N:11][CH:12]=[C:13]([CH:30]=3)[CH2:14][CH2:15][C:16]3[CH:24]=[C:20]([NH:21][C:22]=1[N:23]=2)[CH:19]=[CH:18][C:17]=3[O:25][CH2:26][C:27](O)=[O:28].[N:31]1([C:37]([O:39][C:40]([CH3:43])([CH3:42])[CH3:41])=[O:38])[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1>>[Cl:3][C:4]1[CH:5]=[N:6][C:7]2[NH:8][C:9]3[CH:10]=[N:11][CH:12]=[C:13]([CH:30]=3)[CH2:14][CH2:15][C:16]3[CH:24]=[C:20]([NH:21][C:22]=1[N:23]=2)[CH:19]=[CH:18][C:17]=3[O:25][CH2:26][C:27]([N:34]1[CH2:35][CH2:36][N:31]([C:37]([O:39][C:40]([CH3:43])([CH3:42])[CH3:41])=[O:38])[CH2:32][CH2:33]1)=[O:28]

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 69014357HCID 69014357, compound

Product 1

HCID 57962633HCID 57962633, compound

Procedure

The desired compound was prepared according to the procedure of Example D152 using {[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]oxy}acetic acid dihydrochloride and tert-butyl piperazine-1-carboxylate as the starting materials. LCMS for C23H25ClN5O3 (M+H)+: m/z=454.1. This material was used immediately in the next step.

Sources & evidence

ORD record
ord-714eba0568b04e1186f0398d77464c87
Source dataset
uspto-grants-2014_10
Patent number
US08871753B2

Reaction notes

Loading…