2-Fluorobenzenesulphonyl chloride → 6-Chloro-12-(2-{4-[(2-fluorophenyl)sulfonyl]piperazin-1-yl}-2-oxoethoxy)-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaene bis(trifluoroacetate)

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Reaction Steps

The desired compound was prepared according to the procedure of Example D20, step A, using 6-chloro-12-(2-oxo-2-piperazin-1-ylethoxy)-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaene tris(trifluoroacetate) and 2-fluorobenzenesulphonyl chloride as the starting materials in 50% yield. LCMS for C29H28ClFN7O4S (M+H)+: m/z=624.0.

Provenance & Evidence