HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Difluorobenzoyl chloride → 6-Chloro-12-{2-[4-(2,4-difluorobenzoyl)piperazin-1-yl]-2-oxoethoxy}-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaene bis(trifluoroacetate)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Difluorobenzoyl chloride | HCID 588081 | — |
| Reactant | 6-Chloro-12-(2-oxo-2-piperazin-1-ylethoxy)-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaene tris(trifluoroacetate) | HCID 86636393 | — |
| Product | 6-Chloro-12-{2-[4-(2,4-difluorobenzoyl)piperazin-1-yl]-2-oxoethoxy}-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaene bis(trifluoroacetate) | HCID 86636397 | 30% |
Reaction Steps
The desired compound was prepared according to the procedure of Example D94 using 6-chloro-12-(2-oxo-2-piperazin-1-ylethoxy)-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaene tris(trifluoroacetate) and 2,4-difluorobenzoyl chloride as the starting materials in 30% yield. LCMS for C30H27ClF2N7O3 (M+H)+: m/z=606.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08871753B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-33c46e28b7a6405d9b945ecfb31cd603 |
| Source note | uspto-grants-2014_10 |