Isoxazole-5-carbonyl chloride → 6-Chloro-12-{2-[4-(isoxazol-5-ylcarbonyl)piperazin-1-yl]-2-oxoethoxy}-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaene bis(trifluoroacetate)

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Reaction Steps

The desired compound was prepared according to the procedure of Example D94 using 6-chloro-12-(2-oxo-2-piperazin-1-ylethoxy)-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaene tris(trifluoroacetate) and isoxazole-5-carbonyl chloride as the starting materials in 60% yield. LCMS for C27H26ClN8O4 (M+H)+: m/z=561.0.

Provenance & Evidence