2,5-Dioxopyrrolidin-1-yl 2-cyanoacetate → 3-[4-({[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]oxy}acetyl)piperazin-1-yl]-3-oxopropanenitrile bis(trifluoroacetate)

Participants

Reaction Steps

The desired compound was prepared according to the procedure of Example D94 using 6-chloro-12-(2-oxo-2-piperazin-1-ylethoxy)-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaene tris(trifluoroacetate) and 3-[(2,5-dioxopyrrolidin-1-yl)oxy]-3-oxopropanenitrile as the starting materials in 60% yield. LCMS for C26H26ClN8O3 (M+H)+: m/z=533.0.

Provenance & Evidence