4-Chloro-6-ethoxypyrimidin-2-amine → HCID 13851656, compound

HRID 542081Notes

Reaction equation

HRID 542081 reaction equation
[CH2:1]([S:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[S:13]([N:16]=[C:17]=[O:18])(=[O:15])=[O:14])(=[O:6])=[O:5])[CH2:2][CH3:3].[NH2:19][C:20]1[N:25]=[C:24]([Cl:26])[CH:23]=[C:22]([O:27][CH2:28]C)[N:21]=1>C(#N)C>[Cl:26][C:24]1[CH:23]=[C:22]([O:27][CH3:28])[N:21]=[C:20]([NH:19][C:17]([NH:16][S:13]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[S:4]([CH2:1][CH2:2][CH3:3])(=[O:6])=[O:5])(=[O:15])=[O:14])=[O:18])[N:25]=1

Participants

4

Reactant 2

HCID 38054384-Chloro-6-ethoxypyrimidin-2-amineHCID 13851651HCID 13851651, compound

Product 1

HCID 13851656HCID 13851656, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a suspension of 2-propylsulfonylbenzenesulfonyl isocyanate (1.74 g, 6.00 mmol) in dry acetonitrile (25 ml) was added 2-amino-4-chloro-6-ethoxypyrimidine (1.00 g, 6.00 mmol). After stirring at room temperature overnight, the reaction mixture was filtered to yield the product as a white powder melting at 193°-195° C.

Workup

  1. filtrationthe reaction mixture was filtered

Sources & evidence

ORD record
ord-82463e5666be4fecb2ddf001c6b8c588
Source dataset
uspto-grants-1987_04
Patent number
US04655821

Reaction notes

Loading…