6-Methoxy-N2,N2-dimethyl-1,3,5-triazine-2,4-diamine → N-[(4-Dimethylamino-6-methoxy-1,3,5-triazin-2-yl)aminocarbonyl]-2-(methylsulfonyl)benzenesulfonamide

HRID 542082Notes

Reaction equation

HRID 542082 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([N:8]([CH3:10])[CH3:9])[N:5]=[C:4]([O:11][CH3:12])[N:3]=1.[CH3:13][S:14]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[S:23]([N:26]=[C:27]=[O:28])(=[O:25])=[O:24])(=[O:16])=[O:15]>C(#N)C>[CH3:10][N:8]([CH3:9])[C:6]1[N:5]=[C:4]([O:11][CH3:12])[N:3]=[C:2]([NH:1][C:27]([NH:26][S:23]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=2[S:14]([CH3:13])(=[O:16])=[O:15])(=[O:25])=[O:24])=[O:28])[N:7]=1

Participants

4

Reactant 2

HCID 7932556-Methoxy-N2,N2-dimethyl-1,3,5-triazine-2,4-diamineHCID 130939682-(Methanesulfonyl)benzene-1-sulfonyl isocyanate

Product 1

HCID 13851662N-[(4-Dimethylamino-6-methoxy-1,3,5-triazin-2-yl)aminocarbonyl]-2-(methylsulfonyl)benzenesulfonamide

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a suspension of 2-amino-4-dimethylamino-6-methoxy-1,3,5-triazine (1.02 g, 6.00 mmol) in dry acetonitrile (30 ml) was added 2-methylsulfonylbenzenesulfonyl isocyanate (1.50 g, 6.00 mmol). After stirring at room temperature overnight, the reaction mixture was filtered and the solid washed with acetonitrile to give the product as a white powder with a melting point of 192°-195° C.

Workup

  1. filtrationthe reaction mixture was filtered
  2. washthe solid washed with acetonitrile

Sources & evidence

ORD record
ord-4fed5cfa5bb248d4ad1fc3800bd0a6a4
Source dataset
uspto-grants-1987_04
Patent number
US04655821

Reaction notes

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