HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-[2-Fluoro-4-(6-chloroquinoxalin-2-yloxy)phenoxy]propionyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-[2-Fluoro-4-(6-chloroquinoxalin-2-yloxy)phenoxy]propionic acid | HCID 13578013 | — |
| Product | 2-[2-Fluoro-4-(6-chloroquinoxalin-2-yloxy)phenoxy]propionyl chloride | HCID 13578015 | — |
Reaction Steps
2-[2-Fluoro-4-(6-chloroquinoxalin-2-yloxy)phenoxy]-propionic acid (1.73 g; 4.77 mmole) was treated with thionyl chloride and the mixture was heated under reflux with stirring for a period of 5 hours. The excess thionyl chloride was removed by distillation under reduced pressure to give 2-[2-fluoro-4-(6-chloroquinoxalin-2-yloxy)phenoxy]-propionyl chloride as a straw coloured oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04655819 |
| Source dataset | uspto-grants-1987_04 |
| ORD ID | ord-95ea28f440fb4dcfbb2926363740cadc |
| Source note | uspto-grants-1987_04 |