反应详情

温度

120 °C

A mixture of 2-chloro-6-fluoroquinoxaline (1.0 g; 5.48 mmole), n-propyl 2-(2-fluoro-4-hydroxyphenoxy)propionate (1.33 g; 5.49 mmole), anhydrous potassium carbonate (0.8 g) and anhydrous dimethylformamide (40 ml) was stirred and heated at a temperature of 120° C. for a period of 3.5 hours. The solvent was evaporated from the reaction mixture under vacuum, the residue was treated with water and the mixture was extracted with diethyl ether. The etherial extract was washed with water, dried over anhydrous magnesium sulfate, filtered, and the solvent was evaporated under vacuum to give a brown oil. The product was purified by preparative thin layer chromatography over silica gel (eluant chloroform/ethanol, 95:5) to give the title compound (0.89 g; 41.8%) as a solid; mp 49°-51° C.

1. customThe solvent was evaporated from the reaction mixture under vacuum
2. additionthe residue was treated with water
3. extractionthe mixture was extracted with diethyl ether
4. extractionThe etherial extract
5. washwas washed with water
6. dry with materialdried over anhydrous magnesium sulfate
7. filtrationfiltered
8. customthe solvent was evaporated under vacuum
9. customto give a brown oil
10. customThe product was purified by preparative thin layer chromatography over silica gel (eluant chloroform/ethanol, 95:5)