1-Benzylpiperazine → 1-Benzyl-4-(benzothiophen-2-yl)piperazine

HRID 54216노트

반응식

HRID 54216 반응식
S[C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[CH:6]=1.[CH2:11]([N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C1(C)C=CC=CC=1>[CH2:11]([N:18]1[CH2:23][CH2:22][N:21]([C:2]2[S:3][C:4]3[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=3[CH:6]=2)[CH2:20][CH2:19]1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

참가 물질

4

반응물 2

HCID 759941-BenzylpiperazineHCID 11073791Benzo[b]thiophene-2-thiol

생성물 1

HCID 217016231-Benzyl-4-(benzothiophen-2-yl)piperazine수율 46.5%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a solution of 2-mercaptobenzothiophene (1.8 g, 10.8 mmol) in toluene under nitrogen was added N-benzylpiperazine (1.88 ml, 10.8 mmol) and the mixture heated at reflux for 1.5 h. Left to cool, concentrated in vacuo and product recrystallised from diethyl etherhexane to yield the title compound (1.55 g), m.p. 160°-161° C.

후처리

  1. temperaturethe mixture heated
  2. temperatureat reflux for 1.5 h
  3. waitLeft
  4. temperatureto cool
  5. concentrationconcentrated in vacuo and product
  6. customrecrystallised from diethyl etherhexane

출처 및 근거

ORD 기록
ord-32f26c8a59094396b0d078b59c42391c
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05622950

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