Nitric Acid → HCID 13590788, compound

Participants

Reaction Steps

5.00 g. (0.0199 mol) of 6'-chloro-1',2',3',4'-tetrahydro-spiro(imidazolidine-5,4'-quinoline)-2,4-dione, formula (V), prepared as described in U.S. Pat. No. 4,235,911, was added to 500 ml of concentrated nitric acid precooled to 7° C. measured internally. After one minute the reaction mixture was poured into 4 liters of ice water and extracted with 2×1 liter of ethyl acetate. The combined organic layers were washed with 1 liter of water, dried over magnesium sulfate, filtered and concentrated to a yellow solid. The solid was slurried in ether/hexane (1/3) filtered and dried in vacuo to provide 5.8 g. (98%) of the title product, m.p. 271° to 274° C. dec.

Provenance & Evidence