Formaldehyde → 1-[Bis(hydroxymethyl)-methyl]-6,7-dimethoxy-3,4-dihydroisoquinoline

Participants

Reaction Steps

To 0.01 mole of 1-(β-hydroxyethyl)-6,7-dimethoxy-3,4-dihydroisoquinoline 2 ml of a 37% aqueous formaldehyde solution are added, and the mixture is boiled in 30 ml of methanol for 2 hours. After evaporation the obtained oily residue is triturated with ether. Crystallization of the obtained product from a mixture of acetone and ether affords the desired compound, which has the same spectral characteristics as the product of Example 1. Melting point: 129° to 131 C.°

Provenance & Evidence