HCID 20207293, compound → HCID 20207297, compound

Participants

Reaction Steps

11.5 g (0.027 mol) of 1-dibenzylamino-3-[3-(1-piperidylmethyl)phenyl]-2-propanol in 90 ml of ethanol and 10 ml of water are hydrogenated at 35° C. and atmospheric pressure in the presence of 0.5 g of palladium/active charcoal (10% Pd). After removal of the catalyst by filtration and evaporation of the solvent, the residue consists of 5.8 g of a colourless oil which, after chromatographic purification with methanol/conc. ammonia (95:5), yields 3.5 g (52%) of the title compound in the form of a colourless oil. ##STR5##

Provenance & Evidence