Hydrazine hydrate (1:1) → HCID 20207296, compound

Participants

Reaction Steps

8.60 g (20 mmol) of 2-[2-hydroxy-3-[5-(1-piperidylmethyl)-2-thienylthio]propyl]-1H-isoindole-1,3-dione and 3,3 ml of hydrazine hydrate (80%) are boiled in 80 ml of ethanol for 3 hours. The residue obtained after concentration of the mixture by evaporation is taken up in 50 ml of water; 8 ml of conc. hydrochloric acid are added and the reaction mixture is filtered. The filtrate is adjusted to pH 12 with conc. sodium hydroxide solution and extracted with 3×40 ml methylene chloride. The organic phase is dehydrated with Na2SO4 and concentrated by evaporation under vacuum. 4.9 g (82% of theoretical) of the title compound are obtained as a light green oil. ##STR7##

Provenance & Evidence