Indole-3-Acetic Acid → trans-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-1H-indole-3-acetamide monohydrochloride

関与物質

反応手順

Trans-N-methyl-2-(1-pyrrolidinyl)cyclohexanamine (0.368 g) was dissolved in methylene chloride (10 ml) and stirred at room temperature. The acid chloride of 3-indole acetic acid (prepared by the action of thionyl chloride on 3-indole acetic acid, 0.35 g) dissolved in methylene chloride (10 ml) was added and let stand for five hours. Ether was added to rapidly stirred solution until no more precipitate appeared. After further rapid stirring for one hour, the precipitate was filtered and dried in a vacuum oven at 90° C. for one hour and stored in a predried bottle. The product was in the form of a black glassy solid (300 mg).

情報源と証拠