HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diazomethane diethylether → methyl 1-(4-(N-methylaminosulfonyl)phenyl)methylene-5-methoxy-2-methyl-1H-3-indenylacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diazomethane diethylether | HCID 21186548 | — |
| Reactant | methyl 1-(4-aminosulfonylphenyl)methylene-5-methoxy-2-methyl-1H-3-indenylacetate | HCID 70401818 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | methyl 1-(4-(N-methylaminosulfonyl)phenyl)methylene-5-methoxy-2-methyl-1H-3-indenylacetate | HCID 67583673 | 29% |
Reaction Steps
A solution of 4a (100 mg) in methanol (20 ml) was treated with excess diazomethane ether solution to give two products. They are separated via preparative tlc using 1500 μm silica gel plates developed 3 times with 5% ethyl acetate in chloroform to give Z methyl 1-(4-(N-methylaminosulfonyl)phenyl)methylene-5-methoxy-2-methyl-1H-3-indenylacetate (6a) (30 mg, 29% yield): m.p. 167°-169° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04656190 |
| Source dataset | uspto-grants-1987_04 |
| ORD ID | ord-444feaece30a4ad5bb8930ec7d2f63d3 |
| Source note | uspto-grants-1987_04 |