Tetrahydrofuran → HCID 20209696, compound

Participants

Reaction Conditions

Reaction Steps

Fifty (50) ml of n-butyl lithium (1.55 in hexane) were transferred via a syringe to a one-necked, round-bottomed flask, under nitrogen, equipped with a magnetic stirrer. Ten (10) grams of 3-Bromofuran in 10 ml of dry tetrahydrofuran (THF) were then added dropwise under nitrogen. Once this addition was complete, the resulting solution was stirred at -78 degrees C. for 1 hour. A pale yellow precipitate formed, and 6.5 g of 1,3-dichlorotetramethyl disiloxane in 10 ml dry THF were then added dropwise at -78 degrees C. under nitrogen. The precipitate slowly disappeared. The solution was then stirred for 4 hours at -78 degrees C.

Provenance & Evidence