Methanesulfonic Acid → N-(2,3-dihydro-benzo[b]furan-7-sulfonyl)-N'-(4-dimethylamino-6-methoxy-1,3,5-triazin-2-yl)-urea

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Reaction Steps

8,0 g of 2,3-dihydro-7-sulfamoyl-benzo[b]furan (0,04 mol) and 7,1 g of diphenyl carbonate (0,04 mol) and 150 ml of acetonitrile are stirred together. To this suspension are added dropwise at 0°-5° C. 7,1 g (0,05 mol) of 1,8-diazabicyclo(5,4,0)-undec-7-ene DBU and the resulting solution is left to stand for 15 hours at room temperature. These are then added dropwise 4,4 g (0,045 mol) of methanesulfonic acid at 0°-5° C. An addition of 6,8 g (0,04 mol) of 2-amino-4-dimethylamino-6-methoxy-triazine is subsequently made and the resulting suspension is refluxed for two hours and the resulting turbid hot solution is filtered.

Provenance & Evidence