Acetonitrile → Debrisoquine

HRID 542286Notes

Reaction equation

HRID 542286 reaction equation
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][NH:2]1.N[N:12]=[CH:13]S(O)(=O)=O.C(#[N:20])C>>[CH:7]1[CH:8]=[CH:9][C:10]2[CH2:1][N:2]([C:13]([NH2:12])=[NH:20])[CH2:3][CH2:4][C:5]=2[CH:6]=1

Participants

4

Reactant 3

HCID 6342AcetonitrileHCID 70461,2,3,4-TetrahydroisoquinolineHCID 3013981Aminoiminomethane-sulphonic acid

Product 1

HCID 2966Debrisoquine

Procedure

Tetrahydroisoquinoline (0.013 m) is treated with aminoiminomethanesulfonic acid (0.01 m) at ambient temperature. After completion of the reaction, it is diluted with acetonitrile, cooled and the solid product is collected by filtration.

Workup

  1. customAfter completion of the reaction, it
  2. temperaturecooled
  3. filtrationthe solid product is collected by filtration

Sources & evidence

ORD record
ord-0cd5d279cd8c49429e14cc8a53a6b393
Source dataset
uspto-grants-1987_04
Patent number
US04656291

Reaction notes

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