反应详情

A solution of 2-(methylsulfonylmethyl) acrylic acid (700 mg, 4.26 mmol) in 20 mL of methanol was charged into a Fisher-Porter bottle along with 10% palladium on carbon catalyst under a nitrogen atmosphere. The reaction vessel was sealed and flushed five times with nitrogen and then five times with hydrogen. The pressure was maintained at 50 psig for 16 h and then the hydrogen was replaced with nitrogen and the solution filtered through a pad of celite to remove the catalyst and the filterate concentrated in vacuo to give 682 mg 96% of 2-(R,S)-methyl-3-methylsulfonyl propionic acid.

1. customThe reaction vessel was sealed
2. customflushed five times with nitrogen
3. temperatureThe pressure was maintained at 50 psig for 16 h
4. filtrationthe solution filtered through a pad of celite
5. customto remove the catalyst
6. concentrationthe filterate concentrated in vacuo