Methyl iodide → HCID 13048892, compound

Participants

Reaction Conditions

Reaction Steps

3.0 g of 4-(2',6'-dimethylbenzyl)-imidazole, 40 ml of toluene, 3.0 g of methyliodide, 0.14 g of tetrabutylammoniumhydrogensulfate and 40 ml of 48% sodium hydroxide are mixed. The mixture is stirred vigorously for 2 hours at 70° C., after which the mixture is cooled and filtered. The toluene layer is separated from the mother liquid, after which it is washed with water and evaporated to dryness. The residue is a mixture of 4-(2',6'-dimethylbenzyl)-3-methylimidazole and 4-(2',6'-dimethylbenzyl)-1-methylimidazole. These two components are separated column chromatographically, eluting the column with a mixture of chloroform and methanol.

Provenance & Evidence