HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetyl chloride → HCID 54547258, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetyl chloride | HCID 6577 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 54283113 | HCID 54283113 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 54547258 | HCID 54547258 | — |
Reaction Steps
12.7 g N-[1-methyl-(ethoxyimino)ethyl]-4,6-dimethoxy-pyrimidine-5-amine and 150 ml dry CH2Cl2 are charged in a sulphonation flask. Thereto are added, dropwise, 6.2 g chloracetylchloride in 25 ml dry CH2Cl2. The reaction temperature rises from 22° to 28°. The reaction mixture is heated under reflux for 2 hours and cooled. Then 10% aqueous NaOH is added, the organic phase partitioned off, dried over Na2SO4 and evaporated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04657579 |
| Source dataset | uspto-grants-1987_04 |
| ORD ID | ord-957df801f7ef462dbebaf93c6c96e155 |
| Source note | uspto-grants-1987_04 |