HCID 14557564, compound → HCID 13922739, compound

Participants

Reaction Steps

A solution of 7.9 g (16.8 mmol) of ethyl 3-[2-(2-diethylphosponoethyl)-phenyl]-2-acetamido-2-carboethoxypropanoate in 40 mL of 6N HCl was stirred at vigorous reflux for 14 h. After cooling to room temperature the reaction mixture was concentrated at reduced pressure yielding an oil. This oil was washed with four 25 mL portions of water then dissolved in 20 mL 95% ethanol and propylene oxide added dropwise. The precipitated crude acid was collected by filtration. Recrystallization from dilute ethanol yielded 4.1 g (90%) as a white solid, mp 241°-243° C. IR(Nujol): 1712.5 cm-1 (C=O). 1H NMR(D2O) δ 1.5-2.2 (m, 2H); 2.6-3.3 (m, 4H); 3.9-4.2 (t, 1H); 7.2 (m, 4H). Anal. Calcd. for C11H16NO5P: C, 48.35; H, 5.90; N, 5.13. Found: C, 48.69; H, 6.16; N, 4.95.

Provenance & Evidence